CRISP3 and Sjogren syndrome: Although no specific role of CRISP3 in ion channel regulation has been reported, the low levels of this protein in lacrimal and salivary gland secretion of patients with Sjögren’s syndrome (Tapinos et al., 2002; Laine et al., 2007) together with the altered ion concentrations reported in these glands (Enger et al., 2014) known to be relevant for their functionality (Konttinen et al., 2006), support the idea that CRISP3 may influence the ion concentration of these glands, likely through an ion channel regulatory ability.