In conclusion, a diagnostic model that combines 18F-FDG PET/CT-related imaging findings, such as the SUVmax of bone lesions, bone changes, and the location of bone lesions, with clinical data, including skeleton-related events, anemia, ALP, LDH, CA19-9, and CEA, might assist in the diagnosis of GC with BM. This evidence concerns the gene CEACAM5 and anemia.