Studies have shown that skeleton-related events (SREs), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) are independent prognostic factors for patients with BM from GC (Park et al., 2011; Turkoz et al., 2014; Lim et al., 2016; Wen et al., 2019; Imura et al., 2020). The gene discussed is CEACAM5; the disease is gastric cancer.