PFKFB4 is a key glycolysis regulator which activates the rate-limiting enzyme phosphofructokinase-1 (PFK-1) in glycolysis via its product fructose-2,6-biphosphate and has been proposed recently as a potential oncogene in HCC (Shen et al., 2021). Here, PFKM is linked to hepatocellular carcinoma.