PFKFB4 and central nervous system cancer: PI3K-AKT signaling has documented an important HCC-promoting pathway (Liao et al., 2019; Zhao et al., 2021), and a recent study has shown that transcriptional enhancement of the PFKFB4 expression promotes glioma malignancy progression by activating PI3K/AKT signaling (Zhang et al., 2021).