PAX6 and cancer: A similar methodology to development of the WAGR Spectrum Care Model was previously utilized by some of the authors to develop a care management model for BWSp, or Beckwith-Wiedemann Spectrum (14, 15), which affects imprinting genes on chromosome 11p15 and represents a distinct heterogenous (epi)genetic disorder from the 11p13 deletion in WAGR, but shares some common characteristics with the WAGR population such as complex care management needs and tumor predisposition requiring cancer screening programs.