While POM121 is highly upregulated in advanced lethal prostate cancer (PC), it is found to promote PC aggressiveness by augmenting the selective importin-dependent nuclear shuttling of oncogenic MYC, E2F1, Androgen receptor (AR), and GATA2 (PC-specific) transcription factors (TFs) (59). The gene discussed is E2F1; the disease is pachyonychia congenita.