The mechanistic underpinnings of C9orf72 in cellular toxicity and ultimately neuronal degeneration dependent Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (ALS/FTD) emphasized the pathologic effects of POM121 depletion downstream of G4C2 repeat RNA expression. The gene discussed is POM121; the disease is amyotrophic lateral sclerosis.