Conversely, the depletion of NDUFA4L2 impaired proliferation/survival of mouse embryonic fibroblasts, HeLa, and RCC4 cell lines (14, 15), suggesting that targeting NDUFA4L2 can provide an effective means to inhibit ccRCC cell proliferation. The gene discussed is COXFA4L2; the disease is nonpapillary renal cell carcinoma.