Results demonstrated that decreasing Ndufa4l2 transcript levels in the mouse kidneys evoked a marked reduction in the accumulation of neutral renal lipids and additionally decreased the level of carbonic anhydrase 9 (Car9) and α-Enolase 1 (Eno1), well-established ccRCC biomarkers. This evidence concerns the gene ENO1 and nonpapillary renal cell carcinoma.