In recent years, the attenuated Salmonella TPIN carrying NK4/IL-2, prepared by Professor Xiaoqin Ha, was shown to efficiently transfect tumor cells in vitro to express the target proteins IL-2 and NK4, and the expression products inhibited HepG2 cell proliferation and migration and inhibited the formation of vessels in chick chorioallantoic membrane. This evidence concerns the gene IL2 and neoplasm.