CD274 and non-small cell lung carcinoma: Currently, the approved drugs of anti-CTLA-4 (ipilimumab), anti-PD-1 (nivolumab and pembrolizumab), anti-PD-L1 (atezolizumab, avelumab, and durvalumab), and their combinations have performed significant improvements in treating advanced NSCLC patients (3–6).