Several commonly deleted loci have been identified on chromosome 10q in the region spanning 10q23 to 10qter, encompassing the allelic loci of a number of genes with well-established tumor-suppressive roles (e.g., MMAC/PTEN, SUFU, FGFR2, and DMBT1) or putative tumor-suppressive roles (e.g., ADD3/MXI1, LGI1, and BTRC) (9, 15–17). The gene discussed is MXI1; the disease is neoplasm.