Multivariate Cox regression analysis of gender, age, stage, cancer type, GAPDHS, ACSBG1, and CYP4A11 found that older (>60 years) age, highly expressed GAPDHS, low expressed ACSBG1, and low expressed CYP4A11 were high-risk factors for lung cancer prognosis (Supplementary Table 6; Supplementary Figure 7). The gene discussed is GAPDHS; the disease is lung cancer.