PKLR and lung cancer: Compared to control lung tissues, 43 differentially expressed MMRGs were identified in lung cancer tissues, including 24 upregulated (ATP4A, ALDH3B2, ATP4B, ALDH3A1, CYP4A22-AS1, ADH1C, GAPDH, PKLR, PPAT, CPT1B, PFKP, PC, PFKP-DT, ALDH1L1, ADH4, GPI, ALDH8A1, ALDH18A1, ATP12A, GAPDHS, NDUFS6, OXCT2, CYC1, and ALDH1L2) and 19 downregulated MMRGs (ADH1B, ACADL, ADH1A, CYP4A26P, PPARG, ALDH1A2, ALDH2, ALDH3B1, CYP4A11, MDH1B, ACSBG1, ACSL4, CYP2U1, CYP4A22, CYP4A27P, ACSL1, PPARGC1A, ACAA2, and PFKFB2).