Compared to control lung tissues, 43 differentially expressed MMRGs were identified in lung cancer tissues, including 24 upregulated (ATP4A, ALDH3B2, ATP4B, ALDH3A1, CYP4A22-AS1, ADH1C, GAPDH, PKLR, PPAT, CPT1B, PFKP, PC, PFKP-DT, ALDH1L1, ADH4, GPI, ALDH8A1, ALDH18A1, ATP12A, GAPDHS, NDUFS6, OXCT2, CYC1, and ALDH1L2) and 19 downregulated MMRGs (ADH1B, ACADL, ADH1A, CYP4A26P, PPARG, ALDH1A2, ALDH2, ALDH3B1, CYP4A11, MDH1B, ACSBG1, ACSL4, CYP2U1, CYP4A22, CYP4A27P, ACSL1, PPARGC1A, ACAA2, and PFKFB2). Here, GAPDH is linked to lung carcinoma.