Moreover, inflammatory reaction was also involved in the process of MIRI; the ischemia injury area has a variety of cytokines, including the interleukin family (IL-1, IL-6, IL-8, etc.), tumor necrosis factor (TNF-α), and NF-κB; in addition to direct effect, inflammatory cytokines can also activate neutrophils and endothelial cells and cause OFRs, microcirculation thrombosis, and vascular endothelial cell dysfunction [11]. This evidence concerns the gene TNF and ischemia.