We further show that IL-4-activated eosinophils shared a transcriptome signature that was similar to eosinophils from Type 2-associated diseases (e.g. asthma) whereas IFN-γ + E. coli-activated eosinophils were similar to eosinophils from a Type 1 associated disease (e.g. colitis). This evidence concerns the gene IFNG and colitis.