CD48 and allergic disease: On the other hand, carbonic anhydrase 4 (Car4), transforming growth factor beta-induced (Tgfbi) and Cd48, which were shown to be markers of eosinophils in setting of allergy and asthma (33), or to support eosinophil adhesion and migration by IL-5 (34), were markedly downregulated (Figure 2H).