PGF and preeclampsia: We have shown that maternal sHLA-G inversely correlates with the level of placental dysfunction, the latter evaluated by maternal levels of the antiangiogenic factor sFlt-1, or by the sFlt-1/PlGF ratio (36), and that fetal polymorphisms in the 3’UTR region of HLA-G are associated with presence of acute atherosis in preeclampsia (24).