An IL-33 connected response has been shown to mediate severe arthritis in mice with the Ncf1 mutation, provided that the immune response is directed towards Col2 in joint cartilage (38), which gave us some clues related to IL-33 and Ncf1. We therefore induced IL-33 and IL-25 treated mouse models using Ncf1 deficient mice. Here, IL25 is linked to arthritic joint disease.