In addition, mice lacking Ncf1 exhibited the reduced growth of implanted melanoma and lung carcinoma tumors, and the protection on the melanoma might be caused by increased Th1 cytokines but the reduced lung carcinoma might be associated with increased Th2 cytokine production, suggesting the diverse immunoregulatory effects of Ncf1 in different disease conditions (15). This evidence concerns the gene NCF1 and melanoma.