he present study evaluates the cytokine profiles of Th1 (IFN-γ, TNF-α), Th2/Treg (IL-5, IL-10), Th9 (IL-9), and Th17 (IL-17) in peripheral blood mononuclear cell (PBMC) supernatants stimulated with soluble egg (SEA) and adult worm (SWAP) antigens from patients with schistosomiasis with different stages of hepatic fibrosis and investigates whether SNPs in IL17A, IL10, and CD209 receptor [dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN)] are associated with this pathogenesis and influence the expression of IL-10 and IL-17 in this population. This evidence concerns the gene IL10 and Hepatic fibrosis.