TLR4 and infection: During the infection of humans with bunyaviruses and HCV, the interaction of platelets in this indirect pathway via the NET network is mediated by FcRɣIIa receptors, and in the case of Dengue virus by glycosylation of these receptors, which leads to a change in the quantitative ratio between IgG1 and IgG2 and the CLEC-2, CLEC-3, DC-SIGN, TLR-4 and TLR-2 markers (1, 10, 37, 39).