TLR4 and infection: This pathway of neutralising viruses by platelets, in the case of infection with Dengue virus, is also associated with the virucidal substances of these cells, or type I IFN – resulting from the expression of IFITM-3 (interferon induced transmembrane -3) particles during the activation of platelets by this virus via the CLEC-2 receptor (C-type lectin-like receptor – 2), DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) (47, 133), as well as TLR-9 (83) and TLR-4 (82).