HMGB1 and cancer: In the case of the neoplastic process or cancer, it has been shown that platelets, as a result of the interaction, mediated by TLR-4 receptors, with neoplastic cells, secrete substances from α granules, such as HMGB1 (high mobility group box 1) protein and TNF-β, which leads to the activation of the immune system and enhancement of inflammation, but also to an increase in the invasiveness of cancer cells (76).