IFNA1 and HIV infectious disease: Other studies (43, 76, 134) have shown that activation of platelets by the cytokine receptor during Dengue virus and HIV infection leads to the synthesis of IFN-α, IFN-β, IL-10 and IL-4 by these cells and activation of T regulatory cells as well as secretion of biologically active substances derived from the EVs of these cells (44, 113).