The high CD8+ T cell- infiltration group exhibited lower expression level of CD207a and higher expression levels of critical immune checkpoint genes, immune suppression scores and an abundance of immunosuppressive cells (M2 macrophages and Th2 cells), which may explain the poor prognosis of ccRCC with high CD8+ T cell infiltration (22, 23). The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.