Recently, sodium-glucose cotransporter 2 inhibitors (SGLT2i) were shown to provide cardiovascular protection and prevent renal function deterioration, moreover, SGLT2i can also inhibit platelet activation and may act synergistically with anti-platelet therapies in the setting of acute myocardial infarction (30–32), and could be of clinical benefit to this vulnerable population. Here, SLC5A2 is linked to acute myocardial infarction.