BMI (P <0.001), Knosp classification (P <0.001), extent of resection (P <0.001), Ki-67 (P <0.001), sphenoid sinus invasion (P =0.001), Hardy classification (P =0.003) and smoking history (P =0.018) were the significant risk factors of tumor recurrence or progression (Table 2). This evidence concerns the gene MKI67 and neoplasm.