Quercetin can reverse palmitate-induced inflammation and insulin resistance by inhibiting ROS production, disruption of mitochondrial membrane potential, activation of NFκB, IL-6 and TNF-α production, and Ser phosphorylation of IRS-1, thus restoring insulin-induced Tyr phosphorylation of IRS-1 and insulin signaling (Guo et al., 2013). The gene discussed is IRS1; the disease is Insulin resistance.