Sleep disturbances were suggested to inhibits the inflow of apolipoprotein E (APOE) in cerebrospinal fluid (CSF) and clearance of APOE in interstitial fluid (ISF), which reduces the removal of Aβ in CSF and increase cerebral Aβ deposition. Aβ plaques also trigger the mislocalization of aquaporin 4 (AQP4) and decrease CSF influx, thus forming a vicious circle. And apnoea or obstructive sleep apnea syndrome was related to higher levels of AD-related neuronal injury biomarkers (ie, P-Tau and T-Tau). This evidence concerns the gene APOE and Alzheimer disease.