Cell viability of GBM cells in ECM1 group was significantly increased by 117.28 ± 6.40% in A172 cells (p < 0.001), 92.73 ± 8.70% in U251 cells (p < 0.001), and 42.53 ± 5.74% in U87 cells (p < 0.001) at 48 h, compared with Control group. The gene discussed is ECM1; the disease is glioblastoma.