In our research, the mechanism of Bru in the treatment of GBM was verified by RNA-sequence array and the results showed that Bru could induce cell apoptosis of GBM via downregulating the expression of ECM1, a 85 kDa secreted glycoprotein first isolated from the mouse osteoblast cell line MN7 in 1994 (Mathieu et al., 1994). This evidence concerns the gene ECM1 and glioblastoma.