On the contrary, down-regulating the expression of ECM1 could significantly suppress the proliferation, migration, and invasion of tumor cells (Huang et al., 2019; Yang et al., 2020), and the underlying mechanism could be mainly related to MMP signaling pathway (Sercu et al., 2008a; Abdel Salam et al., 2015). This evidence concerns the gene ECM1 and neoplasm.