TFEB and Cognitive impairment: Furthermore, evidence suggests that the Tau protein hyperphosphorylation results in the formation of neurofibrillary tangles, which affect cognitive function (Mun et al., 2016), and TFEB can prevent cognitive impairment by selectively targeting the pathological tau species for clearance through the potent activation of multiple cellular degradative pathways (Polito et al., 2014; Wang et al., 2016; Chandra et al., 2018; Song et al., 2020; Xu et al., 2020).