In response to AD, ALP has been shown to regulate amyloid precursor protein (APP) turnover and Aβ metabolism (Nixon and Yang, 2011; Harris and Rubinsztein, 2012), and enhanced TFEB function can stimulate ALP function and promote protein clearance and neuroprotection (Sardiello et al., 2009; Tsunemi et al., 2012). Here, APP is linked to Alzheimer disease.