Table 2 shows that the allele and genotype frequencies of the TFEB rs1062966 and rs14063 SNPs in this study differed between the control and cognitive impairment groups (P < 0.05). The frequency of TFEB rs73733015C allele was higher in the cognitive impairment group than in the control group, and the difference was statistically significant between the two groups (P < 0.05). This evidence concerns the gene TFEB and Cognitive impairment.