It was found that 38 transcription factors were differentially expressed after transient middle cerebral artery occlusion (tMCAO) in mice, with SP1, SPi1, and Stat3 being the most significant (Rakers et al., 2019), and it has been hypothesized that SP1 and Argonaute 1 (AGO1) are the two major genes involved in ischemic stroke (Wei et al., 2020). Here, SP1 is linked to ischemic stroke.