It has been found that certain contractile G protein-coupled receptors are increased in brain tissue after ischemia-reperfusion (I/R) in human cerebral vessels (Edvinsson and Povlsen, 2011), among which the increases in endothelin type A (ETAR) and type B receptors (ETBR) are involved in the pathological process after stroke. The gene discussed is EDNRA; the disease is Stroke.