Pharmacological inhibition of CSF-1R and c-kit with Masitinib [a tyrosine kinase inhibitor targeting the SCF receptor (c-kit) and the platelet derived growth factor (PDGF)] showed reduced immune cell infiltration and amelioration of neuromuscular junction (NMJ) integrity, suggesting an implication of mast cells in the axonopathy in periphery in the ALS pathology (Trias et al., 2016, 2020). Here, KIT is linked to amyotrophic lateral sclerosis.