PTGS2 and amyotrophic lateral sclerosis: In post-mortem spinal cords of ALS patients, increased Cox-2 mast cells – Cox-2 is a key mediator of the inflammation (Chen, 2010) – were detected while they were not present in controls (Graves et al., 2004), Recently, mast cells were described near the altered microvascular elements and surrounding MN cell bodies (Kovacs et al., 2021).