− Increase of classical (CD14+, CD16++) and decrease of non-classical (CD14++, CD16–) monocytes in sALS, fALS patients but also in pre-symptomatic ALS mutant carriers (Butovsky et al., 2012; Zondler et al., 2016). − Differential profiles of gene expression in ALS monocytes (Zondler et al., 2016; Zhao et al., 2017). Here, CD14 is linked to amyotrophic lateral sclerosis.