TSPO and Atrophy: − Symmetrical convolutional atrophy in frontal and anterior lobes, gliosis (Ikeda, 2000; Tolnay and Probst, 2001). − PET scanning: TSPO binding in cortical frontal, mesial temporal, subcortical regions, prefrontal cortex, hippocampal, and parahippocampal regions (Cagnin et al., 2004; Turner et al., 2004; Miyoshi et al., 2010; Chew and Atassi, 2019).