Moreover, circulating monocytes of ALS patients presented functional defects in phagocytosis and migration, and appeared to be skewed toward a more pro-inflammatory phenotype with a TNFα protein release positively correlating with progression rates, and a IL-6 protein release positively correlating with disease burden (Zondler et al., 2016; Zhao et al., 2017; Du et al., 2020). This evidence concerns the gene IL6 and amyotrophic lateral sclerosis.