TSPO and amyotrophic lateral sclerosis: In FTD and ALS-FTD patients, increased TSPO binding were observed in cortical frontal, mesial temporal, subcortical regions, prefrontal cortex, hippocampal, and para-hippocampal regions (Cagnin et al., 2004; Turner et al., 2004; Miyoshi et al., 2010; Chew and Atassi, 2019).