It is a well-known fact that AD, like most other neurodegenerative diseases, is fundamentally a proteinopathy, characterized by two pathologies, i.e., altered protein folding and aggregation of two proteins, namely amyloid β-protein (Aβ) and tau (Holtzman et al., 2012; Ashraf et al., 2014). Here, MAPT is linked to neurodegenerative disease.