It consists of 785 amino acids with a molecular weight of 81kDa and binds to GC- rich motifs through its C2H2 zinc finger motif region (Vellingiri et al., 2020).Sp1, together with other pro-inflammatory transcription factors such as c-Jun/AP-1, Nrf2, NF-κB, and p53, have been found to regulate the expression of prominent genes in AD such as amyloid-beta precursor protein (APP) and beta-secretase 1 (BACE1) (Christensen et al., 2004; Docagne et al., 2004; Citron et al., 2015). Here, APP is linked to Alzheimer disease.