SPHK1 and hematocrit: More interesting, knockout of SphK1 significantly reversed the inflammatory inhibitory effect of atorvastatin, including protein leakage (SphK1−/− HT/Atorva vs. WT HT/Atorva; 0.52 ± 0.07 mg/ml vs. 0.37 ± 0.03 mg/ml, P < 0.01) and cell infiltration in BAL (SphK1−/− HT/Atorva vs. WT HT/Atorva; 2.93 ± 0.45 × 105/ml vs. 0.93 ± 0.23 × 105/ml, P < 0.01, respectively, Figures 1(a) and 1(b)).