Other study showed that ZEB1 as a critical regulator promoted TAMs’ protumoral functions.12 13 Moreover, Chemokine (C-C motif) ligand 18 (CCL18), a chemokine predominantly secreted by M2-TAMs, is related to the metastasis and poor prognosis in breast cancer.14 15 Our results found that in OvCa-TAMs spheroids, CCL18 released by TAMs directly induced the expression of ZEB1 in OvCa. The gene discussed is ZEB1; the disease is breast cancer.