In recently, lncRNA SND1-IT1 was firstly reported to be highly expressed in osteosarcoma, and its knockdown suppressed the proliferation and metastasis of RB cells via modulating miRNA-665/POU2F1, suggesting SND1-IT1 as a tumor promotor in osteosarcoma [13]. This evidence concerns the gene POU2F1 and osteosarcoma.