In this study, we aimed to identify the role of LCN2 in neonatal ARDS and we hypothesized that LCN2 silencing protects from ARDS by inhibiting inflammation, oxidative stress and apoptosis induced by ferroptosis and whether MAPK/ERK pathway is involved in the regulation of LCN2 in ARDS. The gene discussed is LCN2; the disease is acute respiratory distress syndrome.