RNA sequencing (RNA‐seq) on right septal biopsies gathered during diagnostic work‐up in DCM patients carrying a pathogenic genetic variant (TTN, LMNA, RBM20 or MYH7) have revealed clearly distinct transcriptome profiles in TTNtv and LMNA‐DCM, as shown by a principal component analysis. Here, LMNA is linked to familial dilated cardiomyopathy.