The surrounding niche of a cancer, that is, the TME, is composed of fibroblasts, endothelial cells, extracellular matrix (ECM), various immune cells, such as tumour infiltrating lymphocytes (TILs), as well as interactions with human leukocyte antigen class I molecules (HLA-1) expressed on tumour cells, and other tumour-associated factors, such as PD-L1, which together play a crucial role in tumour development [37,38,39,40]. The gene discussed is CD274; the disease is cancer.