On the other hand, miR-143 was downregulated in women with GDM treated with insulin, compared to women treated with a diet and to NGT patients; miR-143 targets the hexokinase-2 (HK-2) enzyme [78], which phosphorylates glucose to produce glucose-6-phosphate, the first step in the glycolytic pathway [79]. This evidence concerns the gene INS and gestational diabetes.