miRNA-29b was downregulated in placental tissue from GDM patients compared to healthy placentas, while increasing the expression of its target gene, the hypoxia-inducible factor 3 subunit alpha (HIF3A), showed that the inhibition of miRNA-29b in the trophoblast HTR8/SVneo cell line enhanced cell proliferation and infiltration [83]. The gene discussed is HIF3A; the disease is gestational diabetes.