In MM, mutations are observed in the H3K36me1/2 methyltransferases nuclear-receptor-binding SET domain 1 (NSD1), multiple myeloma SET-domain-containing protein (MMSET, also known as NSD2 and WHSC1), nuclear-receptor-binding SET domain 3 (NSD3, also known as WHSC1L1) [43,146], and the H3K36me3 methyltransferase SET-domain-containing 2 (SETD2). Here, NSD2 is linked to Miyoshi myopathy.