Additionally, homozygous and heterozygous inactivating mutations in the H3K27me3 demethylase ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, also known as KDM6A) have been identified in a small proportion of AML [154,155], MM lacking the chromosomal translocation t(4;14), and T-ALL [146,156], but not lymphomas that harbour EZH2 gain-of-function mutations [100]. This evidence concerns the gene KDM6A and acute lymphoblastic leukemia.