An example of this approach was the pairing of JQ1 and Vorinostat/SAHA, which exhibited synergistic effect in killing pancreatic cancer cell lines in vivo, treating autochthonous murine tumors in the Ptf1a-Cre, Kras+/LSL-G12D, Trp53loxP/loxP (KPC) model of PDA and controlling primary human xenograft tumors [89]. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.