CGAS and systemic lupus erythematosus: The hypothesis provides some explanations relative to SLE for disease features such as female predominance (Xi involvement), primarily adult onset (accumulation of epigenetic changes from multiple stress events), occurrence of antinuclear autoantibodies (chromatin disruption and DNA sensors, such as cGAS), and occurrence of some cytosolic autoantibodies (nucleolar disruption that leads to abnormal RNPs, such as ribosomal subunits, that are supposed to function in the cytosol).