TGFB1 and leukemia: Despite the importance of the β or α isoforms of this gene to myogenesis, hematopoiesis, cardiomyocyte maturation, cardiac homeostasis, certain types of leukemia, and Notch, TGFβ, and retinoic acid signaling pathways (Table S6), there has been only one study published about epigenetic regulation of ASB2. That report described the ASB2α hematopoiesis-associated proximal promoter as upregulated by retinoid receptors [64].