Functionally, a role for ANRIL lncRNA, transcribed from the INK4 locus in orientation antisense to that of mRNAs encoding tumor suppressors (Ink4a/p14 (p16 in mice), Ink4aArf/p19 and Ink4b/p15) has been shown to participate in PRC1 recruiting to this well known Polycomb target [226]. Here, CDKN2B is linked to neoplasm.