NOX4 and osteoarthritis: Similarly, overexpressed MEG3 inhibited osteoarthritis, ischemic brain injury, and cerebral infarction mediated angiogenesis through the alternation of EC functions via regulating the expression levels of VEGF, VEGFR2, notch signalling pathways, and P53/ NADPH Oxidase 4 (NOX4) axis, respectively [62,63,64,65,66].