In SjS the infiltration of activated CD4(+), CD8(+) T, and (CD19+) B lymphocytes mainly affects the lachrymal and salivary glands leading to a progressive loss of their secretory functions and the development of the “sicca complex”, consisting of xerophthalmia and xerostomia [12,13,23,24]. Here, CD19 is linked to Schwartz-Jampel syndrome.