CD4 and gastric cancer: In addition, this study is only a preliminary study of the role of the miR-128-3p/IL16 signaling axis in modulating the enrichment of CD4+ Tregs in GC, and further extensive in-depth studies, such as in vivo and cohort studies, will help us understand the mechanisms by which the miR-128-3p/IL16 axis mediates immune escape by regulating CD4+ Tregs in GC.