The expression levels of ERS‐autophagy‐related proteins, such as p‐PERK, p‐eIF2α, GRP78, Beclin1, ATG7, and LC3II, all decreased after POL intervention, suggesting that POL might alleviate colitis through the PERK‐eIF2α/Beclin1‐LC3II pathway, inhibiting the phosphorylation of the upstream PERK‐eIF2α pathway and subsequently inhibiting the expression of the autophagy marker proteins Beclin1 and LC3II (Figure 11A‐G). Here, BECN1 is linked to colitis.