HSPA5 and colitis: The expression levels of ERS‐autophagy‐related proteins, such as p‐PERK, p‐eIF2α, GRP78, Beclin1, ATG7, and LC3II, all decreased after POL intervention, suggesting that POL might alleviate colitis through the PERK‐eIF2α/Beclin1‐LC3II pathway, inhibiting the phosphorylation of the upstream PERK‐eIF2α pathway and subsequently inhibiting the expression of the autophagy marker proteins Beclin1 and LC3II (Figure 11A‐G).