Notably, the role of ABI1 in cancer is not always the same; in some cancers, such as PMF, glioblastoma, and prostate cancer, ABI1 expression is downregulated [26, 27, 30, 31], whereas in breast cancer, ABI1 expression is enhanced [32], thus suggesting the tissue and disease‐involving pathway specificity of the role of ABI1 in oncogenic transformation and indicating the importance of mechanistic studies. This evidence concerns the gene ABI1 and Familial prostate cancer.