ABI1 and breast neoplasm: Consistent with this finding, western blot analysis of Abi1 KO breast tumors (tumor lysates from 3 mice/genotype) showed an appreciable reduction in WAVE2 expression in the absence of ABI1, recapitulating previously observed WAVE complex dynamics and dependence of complex stability on Abi1 gene status (Fig. 4A) [16, 17].