These findings allow us to consider ABI1 transcription level as a functional score of indicating (a) this gene locus instability, (b) ER(‐) status of the primary tumor, (c) histologic grading system estimator, and iv) a genetic variable that represents correctly known ranked‐order of breast cancer subtypes that reflect genetic grading and drug sensitivity/resistance of the tumor subtypes/groups. The gene discussed is ABI1; the disease is breast cancer.