First, we established that PyMT transgene induces expression of Abi1 in primary tumors vs. normal mammary gland epithelium of Abi1 floxed mice (Fig. 3G); therefore, we concluded that PyMT mouse recapitulates overexpression of ABI1 observed in human tissue, and thus, it is an appropriate model to examine the role of ABI1 in breast cancer tumor progression. Here, ABI1 is linked to breast cancer.