ABI1 and breast carcinoma: First, we established that PyMT transgene induces expression of Abi1 in primary tumors vs. normal mammary gland epithelium of Abi1 floxed mice (Fig. 3G); therefore, we concluded that PyMT mouse recapitulates overexpression of ABI1 observed in human tissue, and thus, it is an appropriate model to examine the role of ABI1 in breast cancer tumor progression.