Our experimental model results demonstrate the important role of ABI1 gene dosage and expression in the lung metastasis process which may model metastatic potential of CNA and gene expression of ABI1 in patient’s primary breast tumors (Fig. 1A), consistent with histologic high‐aggressive breast cancers (Fig. 1B), and basal‐like subtype (Fig. 1D)—hallmarks of high aggressive invasive breast cancer with polyclonal metastases potential. Here, ABI1 is linked to breast carcinoma.