VEGFA and ischemia: However, the retinal vessels are anatomically narrowed, especially at the arteriovenous junction, at the cribriform plate The crowding effect of the layer, and many intravascular lesions that cause thrombosis Inflammatory diseases of trauma may lead to vascular occlusion.[14, 15] Retina VEGF and inflammatory cytokines induced by ischemia increase vascular permeability and leakage.