However, if they are activated continuously for a long time, they will promote the necrosis of myocardial cells, induce ventricular remodeling, and further progress and deterioration of cardiac function until death.[31] Sacubitril-valsartan can also inhibit the activation of RAAS system, enkephalinase and the degradation of natriuretic peptide.[32, 33] Sacubitril-valsartan should augment this endogenous defence mechanism and could be beneficial in heart failure with both reduced and preserved ejection fraction.[34]. The gene discussed is MME; the disease is heart failure.