SPRY2 and neoplasm: By elucidating the mechanisms by which reversine participates in the miR-21-5p-mediated regulation of sprouty RTK signaling antagonist 2 (SPRY2) and the effect of the same on HBC cell viability, proliferation, apoptosis, migration, invasion, and in-vivo growth, we aim to further clarify the anti-tumor function of reversine and miR-21-5p in HBC.