Our previous studies have indicated that the VEGF/VEGFR signaling pathway was involved in BBB permeability regulation in the occurrence of GBM, and the activation of the VEGF downstream signaling pathway PI3K‐AKT could obviously open the BBB for enhanced intracranial drug delivery with a visible improved anti‐GBM effect.9 The gene discussed is KDR; the disease is glioblastoma.