Data on the expression of the investigated targets were compared with mitotic count, and no difference between melanomas with mitotic count < or > 4/10 HPF (8) was observed for FXR1 neither at gene nor at protein levels, while a significantly difference was observed for LTA4H protein but not gene expression No statistically significant association was observed between LTA4H and FXR1 when their gene and protein expressions were compared with Ki-67 index (adopting a value of 19.5 as a discriminating threshold) (7). The gene discussed is LTA4H; the disease is melanoma.