BLM and mesothelioma: BLM overexpression, in particular, was strongly associated with poor survival in mesothelioma (Figure 13J); these patients exhibited a genome-wide single-base substitution landscape consistent with deficient HDR (“signature 3” positive), as opposed to patients with low BLM expression, who manifested proficient HDR, as assessed by their “signature 3” negative status (Figure 13K; Supplementary Table S14) (Alexandrov et al., 2020).