Similarly, GSEA indicated that KEGG pathways enriched in the low ATF3 group were related to inflammation and immunoregulation, such as antigen processing and presentation, natural killer cell-mediated cytotoxicity, primary immunodeficiency in the GPL570 database, allograft rejection, antigen processing and presentation, and graft versus host disease in the GPL96 database (Figures 7B,D). The gene discussed is ATF3; the disease is inborn error of immunity.