Nowadays, a majority of non-tumor necrosis factor inhibitors, including rituximab, infliximab, adalimumab, abatacept, and tocilizumab, were introduced into clinical practice and improved RA patients’ responses and prognoses (Downey, 2016; Moots et al., 2017; Scott, 2017; Gottenberg et al., 2019; Rubbert-Roth et al., 2020; Humby et al., 2021). The gene discussed is TNF; the disease is rheumatoid arthritis.