Furthermore, we also detected the apoptosis of Sh-ATF3, Sh-Ctrl, ATF3-OE, and Ctrl-OE groups in RA-FLS and MH7A by flow cytometry and found that the proportion of apoptotic cells in the Sh-ATF3 groups was higher than that in the Sh-Ctrl group, while compared with that in the Ctrl-OE group, the proportion of apoptotic cells in the ATF3-OE group was slightly decreased (Figures 9B,C). This evidence concerns the gene ATF3 and rheumatoid arthritis.